Nature Communications (Jul 2020)
NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice
- Psylvia Léger,
- Eliana Nachman,
- Karsten Richter,
- Carole Tamietti,
- Jana Koch,
- Robin Burk,
- Susann Kummer,
- Qilin Xin,
- Megan Stanifer,
- Michèle Bouloy,
- Steeve Boulant,
- Hans-Georg Kräusslich,
- Xavier Montagutelli,
- Marie Flamand,
- Carmen Nussbaum-Krammer,
- Pierre-Yves Lozach
Affiliations
- Psylvia Léger
- CellNetworks—Cluster of Excellence and Virology, University Hospital Heidelberg
- Eliana Nachman
- Center for Molecular Biology of Heidelberg University (ZMBH) and German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance
- Karsten Richter
- DKFZ
- Carole Tamietti
- Structural Virology, Institut Pasteur
- Jana Koch
- CellNetworks—Cluster of Excellence and Virology, University Hospital Heidelberg
- Robin Burk
- Center for Integrative Infectious Diseases Research (CIID), Virology, University Hospital Heidelberg
- Susann Kummer
- Center for Integrative Infectious Diseases Research (CIID), Virology, University Hospital Heidelberg
- Qilin Xin
- University Lyon, INRAE, EPHE, IVPC
- Megan Stanifer
- Center for Integrative Infectious Diseases Research (CIID), Virology, University Hospital Heidelberg
- Michèle Bouloy
- Unité de Génétique Moléculaire des Bunyavirus, Institut Pasteur
- Steeve Boulant
- Center for Integrative Infectious Diseases Research (CIID), Virology, University Hospital Heidelberg
- Hans-Georg Kräusslich
- Center for Integrative Infectious Diseases Research (CIID), Virology, University Hospital Heidelberg
- Xavier Montagutelli
- Mouse Genetics Laboratory, Institut Pasteur
- Marie Flamand
- Structural Virology, Institut Pasteur
- Carmen Nussbaum-Krammer
- Center for Molecular Biology of Heidelberg University (ZMBH) and German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance
- Pierre-Yves Lozach
- CellNetworks—Cluster of Excellence and Virology, University Hospital Heidelberg
- DOI
- https://doi.org/10.1038/s41467-020-17101-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 19
Abstract
Rift Valley fever virus (RVFV) can cause severe diseases in humans, including encephalitis. Here the authors show that NSs, the major virulence factor of RVFV, is an amyloidogenic protein forming fibrils in infected mouse brains and causing increased mortality in mice.
