Nature Communications (Sep 2021)

Adipose tissue-derived neurotrophic factor 3 regulates sympathetic innervation and thermogenesis in adipose tissue

  • Xin Cui,
  • Jia Jing,
  • Rui Wu,
  • Qiang Cao,
  • Fenfen Li,
  • Ke Li,
  • Shirong Wang,
  • Liqing Yu,
  • Gary Schwartz,
  • Huidong Shi,
  • Bingzhong Xue,
  • Hang Shi

DOI
https://doi.org/10.1038/s41467-021-25766-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 18

Abstract

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Activation of brown adipose tissue thermogenesis increases energy expenditure and promotes weight loss in mice. Here the authors identify neurotrophic factor neurotrophin 3 (NT-3) as an adipokine that regulates sympathetic nervous system growth and innervation in adipose tissue and increases white adipose beiging.