Nature Communications (Aug 2019)
Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence
- Chanyoung Song,
- Hathaichanok Phuengkham,
- Young Seob Kim,
- Van Vuong Dinh,
- Inho Lee,
- Il Woo Shin,
- Hong Sik Shin,
- Seung Mo Jin,
- Soong Ho Um,
- Hyunseung Lee,
- Kwan Soo Hong,
- Seon-Mi Jin,
- Eunji Lee,
- Tae Heung Kang,
- Yeong-Min Park,
- Yong Taik Lim
Affiliations
- Chanyoung Song
- Department of Nano Engineering, SKKU Advanced Institute of Nanotechnology (SAINT), and School of Chemical Engineering, Biomedical Institute for Convergence at SKKU, Sungkyunkwan University
- Hathaichanok Phuengkham
- Department of Nano Engineering, SKKU Advanced Institute of Nanotechnology (SAINT), and School of Chemical Engineering, Biomedical Institute for Convergence at SKKU, Sungkyunkwan University
- Young Seob Kim
- Department of Immunology, School of Medicine, Konkuk University
- Van Vuong Dinh
- Department of Nano Engineering, SKKU Advanced Institute of Nanotechnology (SAINT), and School of Chemical Engineering, Biomedical Institute for Convergence at SKKU, Sungkyunkwan University
- Inho Lee
- Department of Nano Engineering, SKKU Advanced Institute of Nanotechnology (SAINT), and School of Chemical Engineering, Biomedical Institute for Convergence at SKKU, Sungkyunkwan University
- Il Woo Shin
- Department of Nano Engineering, SKKU Advanced Institute of Nanotechnology (SAINT), and School of Chemical Engineering, Biomedical Institute for Convergence at SKKU, Sungkyunkwan University
- Hong Sik Shin
- Department of Nano Engineering, SKKU Advanced Institute of Nanotechnology (SAINT), and School of Chemical Engineering, Biomedical Institute for Convergence at SKKU, Sungkyunkwan University
- Seung Mo Jin
- Department of Nano Engineering, SKKU Advanced Institute of Nanotechnology (SAINT), and School of Chemical Engineering, Biomedical Institute for Convergence at SKKU, Sungkyunkwan University
- Soong Ho Um
- Department of Nano Engineering, SKKU Advanced Institute of Nanotechnology (SAINT), and School of Chemical Engineering, Biomedical Institute for Convergence at SKKU, Sungkyunkwan University
- Hyunseung Lee
- Bioimaging Research Team, Korea Basic Science Institute
- Kwan Soo Hong
- Bioimaging Research Team, Korea Basic Science Institute
- Seon-Mi Jin
- School of Materials Science and Engineering, Gwangju Institute of Science and Technology
- Eunji Lee
- School of Materials Science and Engineering, Gwangju Institute of Science and Technology
- Tae Heung Kang
- Department of Immunology, School of Medicine, Konkuk University
- Yeong-Min Park
- Department of Immunology, School of Medicine, Konkuk University
- Yong Taik Lim
- Department of Nano Engineering, SKKU Advanced Institute of Nanotechnology (SAINT), and School of Chemical Engineering, Biomedical Institute for Convergence at SKKU, Sungkyunkwan University
- DOI
- https://doi.org/10.1038/s41467-019-11730-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
The limited efficacy of current immunotherapy suggests low antigen-specific T cells and immunosuppressive factors in tumor microenvironment (TME). Here, the authors develop a syringeable immunomodulatory multi-domain nanogel that can reprogram the TME and induce enhanced cancer immunotherapy.
