Human induced pluripotent stem cell line HMUi001-A derived from corneal stromal cells

Timur Bikkuzin; Yan Shi; Baoqi Sun; Yiyuan Guo; Xin Jin; Zhenbo Han; Valentin Pavlov; Hong Zhang

Stem Cell Research (May 2019)

Human induced pluripotent stem cell line HMUi001-A derived from corneal stromal cells

Timur Bikkuzin,
Yan Shi,
Baoqi Sun,
Yiyuan Guo,
Xin Jin,
Zhenbo Han,
Valentin Pavlov,
Hong Zhang

Affiliations

Timur Bikkuzin: Eye Hospital, First Affiliated Hospital of Harbin Medical University, Harbin, China; Central Laboratory of Scientific Research, Bashkir State Medical University, Ufa, Russian Federation
Yan Shi: Eye Hospital, First Affiliated Hospital of Harbin Medical University, Harbin, China
Baoqi Sun: Eye Hospital, First Affiliated Hospital of Harbin Medical University, Harbin, China
Yiyuan Guo: Eye Hospital, First Affiliated Hospital of Harbin Medical University, Harbin, China
Xin Jin: Eye Hospital, First Affiliated Hospital of Harbin Medical University, Harbin, China
Zhenbo Han: Department of Pharmacy, the Second Affiliated Hospital of Harbin Medical University (Institute of Clinical Pharmacy, the Heilongjiang Key Laboratory of Drug Research, Harbin Medical University), Harbin, China; Department of Pharmacology (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China
Valentin Pavlov: Central Laboratory of Scientific Research, Bashkir State Medical University, Ufa, Russian Federation
Hong Zhang: Eye Hospital, First Affiliated Hospital of Harbin Medical University, Harbin, China; Corresponding author.

Journal volume & issue: Vol. 37

Abstract

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A human corneal stroma induced pluripotent stem cell (HMUi001-A) line was created from primary cultured human corneal fibroblasts. Reprogramming was performed using episomal vector delivery of OCT4, SOX2, KLF4, L-MYC and LIN28. Further characterization of the HMUi001-A confirmed that the cell line was pluripotent, free from Epstein Barr viral genome, and retained normal karyotype.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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