Comparison of <i>In Vitro</i> Hair Growth Promotion and Anti-Hair Loss Potential of Thai Rice By-Product from <i>Oryza sativa</i> L. cv. Buebang 3 CMU and Sanpatong
Anurak Muangsanguan,
Warintorn Ruksiriwanich,
Chaiwat Arjin,
Sansanee Jamjod,
Chanakan Prom-u-Thai,
Pensak Jantrawut,
Pornchai Rachtanapun,
Patipan Hnorkaew,
Apinya Satsook,
Mathukorn Sainakham,
Juan Manuel Castagnini,
Korawan Sringarm
Affiliations
Anurak Muangsanguan
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand
Warintorn Ruksiriwanich
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand
Chaiwat Arjin
Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand
Sansanee Jamjod
Department of Plant and Soil Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand
Chanakan Prom-u-Thai
Department of Plant and Soil Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand
Pensak Jantrawut
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand
Pornchai Rachtanapun
Center of Excellence in Agro Bio-Circular-Green Industry (Agro BCG), Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand
Patipan Hnorkaew
Office of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand
Apinya Satsook
Office of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand
Mathukorn Sainakham
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand
Juan Manuel Castagnini
Research Group in Innovative Technologies for Sustainable Food (ALISOST), Department of Preventive Medicine and Public Health, Food Science, Toxicology and Forensic Medicine, Faculty of Pharmacy, Universitat de València, Avenida Vicent Andrés Estellés s/n, 46100 Burjassot, Spain
Korawan Sringarm
Center of Excellence in Agro Bio-Circular-Green Industry (Agro BCG), Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand
The bioactive compounds in herbal extracts may provide effective hair loss treatments with fewer side effects compared to synthetic medicines. This study evaluated the effects of Buebang 3 CMU and Sanpatong rice bran extracts, macerated with dichloromethane or 95% ethanol, on hair growth promotion and hair loss prevention. Overall, Buebang 3 CMU extracts contained significantly higher levels of bioactive compounds, including γ-oryzanol, tocopherols, and various polyphenols such as phytic acid, ferulic acid, and chlorogenic acid, compared to Sanpatong extracts. Additionally, ethanolic extracts demonstrated greater bioactive content and antioxidant activities than those extracted with dichloromethane. These compounds enhanced the proliferation of human hair follicle dermal papilla cells (HFDPCs) by 124.28 ± 1.08% (p p SRD5A1, SRD5A2, and SRD5A3 expression—key pathways in hair loss—by 2-fold and 1.5-fold more than minoxidil and finasteride, respectively. These findings suggest that Et-BB3-CMU holds promise for promoting hair growth and preventing hair loss.
