Evaluation of Fibrin Sealants and Tissue Adhesives in Oral Surgery for Patients with Bleeding Disorders

Abstract

OBJECTIVE: The aim of this study was to evaluate the efficiency of two local haemostatic agents administered together with preoperative dose of replacement therapy for oral surgical procedures in patients with bleeding disorders METHODS: Twenty-one patients were divided into three groups randomly. Patients in Group 1 (n=7) received preoperative replacement therapy with postoperative fibrin sealant application in the surgical site. Patients in Group 2 (n=7) received preoperative replacement therapy with postoperative tissue adhesive application in the surgical site. Patients in Group 3 (n=7) were given total dose of replacement therapy pre- and postoperatively. RESULTS: No postoperative bleeding was observed in 17 patients including five patients in Group 1 (71.42%), six patients in Group 2 (85.71%) and six patients in Group 3 (85.71%). Haemorrhagic complication was observed in only four patients among all groups. CONCLUSION: We conclude that utilization of fibrin sealants and tissue adhesives in oral surgery is beneficial due to the lessened amount of factor concentrates used for replacement therapy and the rapid haemostasis at the operation side to perform serial surgical procedures in the same session.

Keywords

• fibrin sealants
• tissue adhesive
• tooth extraction
• haemophilia
• bleeding disorders