Cancers (Feb 2023)
COVID-19 Severity and Survival over Time in Patients with Hematologic Malignancies: A Population-Based Registry Study
- Joaquín Martínez-López,
- Javier De la Cruz,
- Rodrigo Gil-Manso,
- Adrián Alegre,
- Javier Ortiz,
- Pilar Llamas,
- Yolanda Martínez,
- José-Ángel Hernández-Rivas,
- Isabel González-Gascón,
- Celina Benavente,
- Pablo Estival Monteliu,
- Víctor Jiménez-Yuste,
- Miguel Canales,
- Mariana Bastos,
- Mi Kwon,
- Susana Valenciano,
- Marta Callejas-Charavia,
- Javier López-Jiménez,
- Pilar Herrera,
- Rafael Duarte,
- Lucía Núñez Martín-Buitrago,
- Pedro Sanchez Godoy,
- Cristina Jacome Yerovi,
- Pilar Martínez-Barranco,
- María García Roa,
- Cristian Escolano Escobar,
- Arturo Matilla,
- Belén Rosado Sierra,
- María Concepción Aláez-Usón,
- Keina Quiroz-Cervantes,
- Carmen Martínez-Chamorro,
- Jaime Pérez-Oteyza,
- Rafael Martos-Martinez,
- Regina Herráez,
- Clara González-Santillana,
- Juan Francisco Del Campo,
- Arancha Alonso,
- Adolfo de la Fuente,
- Adriana Pascual,
- Rosalía Bustelos-Rodriguez,
- Ana Sebrango,
- Elena Ruiz,
- Eriel Alexis Marcheco-Pupo,
- Carlos Grande,
- Ángel Cedillo,
- Carlos Lumbreras,
- Andrés Arroyo Barea,
- José Manuel Casas-Rojo,
- Maria Calbacho,
- José Luis Diez-Martín,
- Julio García-Suárez
Affiliations
- Joaquín Martínez-López
- Hematology Department, Hospital Universitario 12 de Octubre, imas12, Universidad Complutense, CNIO-ISCIII, CIBERONC, 28041 Madrid, Spain
- Javier De la Cruz
- Research Institute, Hospital Universitario 12 de Octubre, imas12, 28041 Madrid, Spain
- Rodrigo Gil-Manso
- Hematology Department, Hospital Universitario 12 de Octubre, imas12, Universidad Complutense, CNIO-ISCIII, CIBERONC, 28041 Madrid, Spain
- Adrián Alegre
- Hematology Department, Hospital Universitario de La Princesa, IIS-HUP, 28006 Madrid, Spain
- Javier Ortiz
- Hematology Department, Hospital Universitario de La Princesa, IIS-HUP, 28006 Madrid, Spain
- Pilar Llamas
- Hematology Department, Hospital Fundación Jiménez Díaz, Health Research Institute IIS-FJD, 28040 Madrid, Spain
- Yolanda Martínez
- Hematology Department, Hospital Fundación Jiménez Díaz, Health Research Institute IIS-FJD, 28040 Madrid, Spain
- José-Ángel Hernández-Rivas
- Hematology Department, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain
- Isabel González-Gascón
- Hematology Department, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain
- Celina Benavente
- Hematology Department, Hospital Clínico San Carlos, 28040 Madrid, Spain
- Pablo Estival Monteliu
- Hematology Department, Hospital Clínico San Carlos, 28040 Madrid, Spain
- Víctor Jiménez-Yuste
- Hematology Department, Hospital Universitario La Paz, 28046 Madrid, Spain
- Miguel Canales
- Hematology Department, Clínica Universidad de Navarra, 28027 Madrid, Spain
- Mariana Bastos
- Hematology Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, 28007 Madrid, Spain
- Mi Kwon
- Hematology Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, 28007 Madrid, Spain
- Susana Valenciano
- Hematology Department, Hospital Universitario HM Sanchinarro, 28050 Madrid, Spain
- Marta Callejas-Charavia
- Hematology Department, Hospital Universitario Príncipe de Asturias, Universidad de Alcalá, Alcalá de Henares, 28805 Madrid, Spain
- Javier López-Jiménez
- Hematology Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain
- Pilar Herrera
- Hematology Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain
- Rafael Duarte
- Hematology Department, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain
- Lucía Núñez Martín-Buitrago
- Hematology Department, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain
- Pedro Sanchez Godoy
- Hematology Department, Hospital Universitario Severo Ochoa, 28911 Madrid, Spain
- Cristina Jacome Yerovi
- Hematology Department, Hospital Universitario Severo Ochoa, 28911 Madrid, Spain
- Pilar Martínez-Barranco
- Hematology Department, Hospital Universitario Fundación Alcorcón, 28922 Madrid, Spain
- María García Roa
- Hematology Department, Hospital Universitario Fundación Alcorcón, 28922 Madrid, Spain
- Cristian Escolano Escobar
- Hematology Department, Hospital Universitario de Getafe, 28905 Madrid, Spain
- Arturo Matilla
- Hematology Department, Hospital Central de la Defensa Gómez Ulla, 28047 Madrid, Spain
- Belén Rosado Sierra
- Hematology Department, Hospital Universitario Rey Juan Carlos, Móstoles, 28933 Madrid, Spain
- María Concepción Aláez-Usón
- Hematology Department, Hospital HLA Universitario Moncloa, 28027 Madrid, Spain
- Keina Quiroz-Cervantes
- Hematology Department, Hospital Universitario de Móstoles, 28935 Madrid, Spain
- Carmen Martínez-Chamorro
- Hematology Department, Hospital Universitario Quirónsalud Madrid, Pozuelo de Alarcón, 28223 Madrid, Spain
- Jaime Pérez-Oteyza
- Hematology Department, Hospital Universitario HM Sanchinarro, 28050 Madrid, Spain
- Rafael Martos-Martinez
- Hematology Department, Hospital Universitario General de Villalba, Villalba, 28400 Madrid, Spain
- Regina Herráez
- Hematology Department, Hospital Universitario Infanta Sofía, San Sebastián de Los Reyes, 28702 Madrid, Spain
- Clara González-Santillana
- Hematology Department, Hospital Universitario de Fuenlabrada, 28942 Madrid, Spain
- Juan Francisco Del Campo
- Hematology Department, Hospital Universitario del Henares, Coslada, 28822 Madrid, Spain
- Arancha Alonso
- Hematology Department, Hospital Ruber, 28006 Madrid, Spain
- Adolfo de la Fuente
- Hematology Department, MD Anderson Cancer Center Madrid, 28033 Madrid, Spain
- Adriana Pascual
- Hematology Department, Hospital Universitario Infanta Elena, Valdemoro, 28340 Madrid, Spain
- Rosalía Bustelos-Rodriguez
- Hematology Department, Hospital Universitario del Sureste, Arganda del Rey, 28500 Madrid, Spain
- Ana Sebrango
- Hematology Department, Hospital Universitario de Torrejón, 28850 Madrid, Spain
- Elena Ruiz
- Hematology Department, Hospital Universitario del Tajo, Aranjuez, 28300 Madrid, Spain
- Eriel Alexis Marcheco-Pupo
- Hematology Department, Hospital Universitario Infanta Cristina, Parla, 28980 Madrid, Spain
- Carlos Grande
- Hematology Department, Clínica Universidad de Navarra, 28027 Madrid, Spain
- Ángel Cedillo
- Asociación Madrileña de Hematología y Hemoterapia (AMHH), 28040 Madrid, Spain
- Carlos Lumbreras
- Internal Medicine Department, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain
- Andrés Arroyo Barea
- Hematology Department, Hospital Universitario 12 de Octubre, imas12, Universidad Complutense, CNIO-ISCIII, CIBERONC, 28041 Madrid, Spain
- José Manuel Casas-Rojo
- Internal Medicine Department, Hospital Universitario Infanta Cristina, Parla, 28980 Madrid, Spain
- Maria Calbacho
- Hematology Department, Hospital Universitario 12 de Octubre, imas12, Universidad Complutense, CNIO-ISCIII, CIBERONC, 28041 Madrid, Spain
- José Luis Diez-Martín
- Hematology Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, 28007 Madrid, Spain
- Julio García-Suárez
- Hematology Department, Hospital Universitario Príncipe de Asturias, Universidad de Alcalá, Alcalá de Henares, 28805 Madrid, Spain
- DOI
- https://doi.org/10.3390/cancers15051497
- Journal volume & issue
-
Vol. 15,
no. 5
p. 1497
Abstract
Mortality rates for COVID-19 have declined over time in the general population, but data in patients with hematologic malignancies are contradictory. We identified independent prognostic factors for COVID-19 severity and survival in unvaccinated patients with hematologic malignancies, compared mortality rates over time and versus non-cancer inpatients, and investigated post COVID-19 condition. Data were analyzed from 1166 consecutive, eligible patients with hematologic malignancies from the population-based HEMATO-MADRID registry, Spain, with COVID-19 prior to vaccination roll-out, stratified into early (February–June 2020; n = 769 (66%)) and later (July 2020–February 2021; n = 397 (34%)) cohorts. Propensity-score matched non-cancer patients were identified from the SEMI-COVID registry. A lower proportion of patients were hospitalized in the later waves (54.2%) compared to the earlier (88.6%), OR 0.15, 95%CI 0.11–0.20. The proportion of hospitalized patients admitted to the ICU was higher in the later cohort (103/215, 47.9%) compared with the early cohort (170/681, 25.0%, 2.77; 2.01–3.82). The reduced 30-day mortality between early and later cohorts of non-cancer inpatients (29.6% vs. 12.6%, OR 0.34; 0.22–0.53) was not paralleled in inpatients with hematologic malignancies (32.3% vs. 34.8%, OR 1.12; 0.81–1.5). Among evaluable patients, 27.3% had post COVID-19 condition. These findings will help inform evidence-based preventive and therapeutic strategies for patients with hematologic malignancies and COVID-19 diagnosis.
Keywords