Nature Communications (Aug 2018)

A widespread alternate form of cap-dependent mRNA translation initiation

  • Columba de la Parra,
  • Amanda Ernlund,
  • Amandine Alard,
  • Kelly Ruggles,
  • Beatrix Ueberheide,
  • Robert J. Schneider

DOI
https://doi.org/10.1038/s41467-018-05539-0
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

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Binding of eIF4E to the 5′ cap of mRNAs is a key early step in canonical translation initiation, but the requirement for eIF4E is not universal. Here the authors show that the eIF4G homolog DAP5 interacts with eIF3 to promote cap-dependent translation of a significant number of mRNA in an eIF4E-independent manner.