Role of Viral miRNAs and Epigenetic Modifications in Epstein-Barr Virus-Associated Gastric Carcinogenesis

Oxidative Medicine and Cellular Longevity. 2016;2016 DOI 10.1155/2016/6021934

 

Journal Homepage

Journal Title: Oxidative Medicine and Cellular Longevity

ISSN: 1942-0900 (Print); 1942-0994 (Online)

Publisher: Hindawi Limited

LCC Subject Category: Science: Biology (General): Cytology

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML, ePUB, XML

 

AUTHORS


Aldo Giudice (Epidemiology Unit, National Cancer Institute of Naples “G. Pascale Foundation”, IRCCS, 80131 Naples, Italy)

Giovanni D’Arena (Department of Onco-Hematology, IRCCS, Cancer Referral Center of Basilicata, 85028 Rionero in Vulture, Italy)

Anna Crispo (Epidemiology Unit, National Cancer Institute of Naples “G. Pascale Foundation”, IRCCS, 80131 Naples, Italy)

Mario Felice Tecce (Department of Pharmacy, University of Salerno, Fisciano, 84084 Salerno, Italy)

Flavia Nocerino (Epidemiology Unit, National Cancer Institute of Naples “G. Pascale Foundation”, IRCCS, 80131 Naples, Italy)

Maria Grimaldi (Epidemiology Unit, National Cancer Institute of Naples “G. Pascale Foundation”, IRCCS, 80131 Naples, Italy)

Emanuela Rotondo (Epidemiology Unit, National Cancer Institute of Naples “G. Pascale Foundation”, IRCCS, 80131 Naples, Italy)

Anna Maria D’Ursi (Department of Pharmacy, University of Salerno, Fisciano, 84084 Salerno, Italy)

Mario Scrima (Department of Pharmacy, University of Salerno, Fisciano, 84084 Salerno, Italy)

Massimiliano Galdiero (Department of Experimental Medicine II, University of Naples, 81055 Naples, Italy)

Gennaro Ciliberto (Scientific Direction, National Cancer Institute “G. Pascale Foundation”, IRCCS, 80131 Naples, Italy)

Mario Capunzo (Department of Medicine and Surgery, University of Salerno, Baronissi, 84081 Salerno, Italy)

Gianluigi Franci (Department of Experimental Medicine II, University of Naples, 81055 Naples, Italy)

Antonio Barbieri (Animal Facility Unit, National Cancer Institute of Naples “G. Pascale Foundation”, IRCCS, 80131 Naples, Italy)

Sabrina Bimonte (Division of Abdominal Surgical Oncology, Hepatobiliary Unit, National Cancer Institute “G. Pascale Foundation”, IRCCS, 80131 Naples, Italy)

Maurizio Montella (Epidemiology Unit, National Cancer Institute of Naples “G. Pascale Foundation”, IRCCS, 80131 Naples, Italy)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 15 weeks

 

Abstract | Full Text

MicroRNAs are short (21–23 nucleotides), noncoding RNAs that typically silence posttranscriptional gene expression through interaction with target messenger RNAs. Currently, miRNAs have been identified in almost all studied multicellular eukaryotes in the plant and animal kingdoms. Additionally, recent studies reported that miRNAs can also be encoded by certain single-cell eukaryotes and by viruses. The vast majority of viral miRNAs are encoded by the herpesviruses family. These DNA viruses including Epstein-Barr virus encode their own miRNAs and/or manipulate the expression of cellular miRNAs to facilitate respective infection cycles. Modulation of the control pathways of miRNAs expression is often involved in the promotion of tumorigenesis through a specific cascade of transduction signals. Notably, latent infection with Epstein-Barr virus is considered liable of causing several types of malignancies, including the majority of gastric carcinoma cases detected worldwide. In this review, we describe the role of the Epstein-Barr virus in gastric carcinogenesis, summarizing the functions of the Epstein-Barr virus-encoded viral proteins and related epigenetic alterations as well as the roles of Epstein-Barr virus-encoded and virally modulated cellular miRNAs.