Correlation of dyslipidemia with HBA1c, fasting plasma glucose and BMI in patients with PCOS and Healthy women

Abstract

Background: Polycystic ovary syndrome (PCOS) is a complicated endocrine ailment of unknown reason, it additionally impacts metabolic pathways. Obesity, insulin resistance (IR), and dyslipidemia are common in PCOS cases. Women with PCOS have a greater prevalence of atherosclerosis and cardiovascular illnesses. Objective: To determine the lipid profile and correlate with HBA1c levels in women with PCOS compared with non-PCOS women to identify the diabetic and cardiovascular risk. Material and Methods: A total of 55 subjects were recruited between, out of which 26 were cases (PCOS) and 29 were controls (healthy women). HBA1c, fasting plasma glucose (FBS), and lipid profile values were notes. Using SPSS software statically analysis were calculated. Results: The serum levels of TC, TAG, VLDL, and LDL cholesterol are significantly increased in women with PCOS compared with healthy women, except for the HDL level, which is significantly decreased. A statistically significant positive correlation was noticed between HBA1c, total cholesterol, triglycerides, and VLDL at a 5% p-value. Conclusion: Women with PCOS are more prone to dyslipidemia, which is the major determinant of cardiovascular diseases and other metabolic disorders; their reduction plays a significant role in the primary prevention of CVD. Hence they should be screened routinely for a lipid profile and hyperglycemic state to prevent cardiovascular complications and other metabolic syndromes.

Keywords

• polycystic ovary syndrome
• total cholesterol
• triglycerides
• high density lipoprotein- cholesterol (hdl-c)
• low density lipoprotein cholesterol (ldl-c)