Nanomaterial-Based Repurposing of Macrophage Metabolism and Its Applications

Abstract

Highlights A large-scale metabolic adaptation in M1-polarized macrophages compared with M2 macrophages, along with multiple altered metabolite parameters that can serve as potential targets, have been discussed. Nanomaterial-based repurposing of macrophage metabolism and its applications are systematically summarized and illustrated using representative examples. Potential challenges, additional information about future research objectives, and priorities of nanomaterial-based macrophage immunotherapy are highlighted.

Keywords

• Immunomodulatory nanomaterial
• Macrophage polarization
• Macrophage metabolic reprogramming
• Immune engineering