International Journal of Nanomedicine (Jul 2022)
Efficiency of Multifunctional Antibacterial Hydrogels for Chronic Wound Healing in Diabetes: A Comprehensive Review
Abstract
Jia-Ying Ji,1,* Dan-Yang Ren,2,* Ying-Zheng Weng3 1Department of Plastic Surgery, The Affiliated People’s Hospital of Ningbo University, Ningbo, 315100, People’s Republic of China; 2Zhejiang University School of Medicine, Hangzhou, 310016, People’s Republic of China; 3Department of Cardiology, Zhejiang Hospital, Hangzhou, 310016, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jia-Ying Ji, Department of Plastic Surgery, The Affiliated People’s Hospital of Ningbo University, 251 East Baizhang Road, Ningbo, 315100, People’s Republic of China, Email [email protected]: Diabetic chronic wounds or amputation, which are complications of diabetes mellitus (DM), are a cause of great suffering for diabetics. In addition to the lack of oxygen, elevated reactive oxygen species (ROS) and reduced vascularization, microbial invasion is also a critical factor that induces non-healing chronic diabetic wounds, ie, wounds still remaining in the stage of inflammation, after which the wound tissue begins to age and becomes necrotic. To clear up the infection, alleviate the inflammation in the wound and prevent necrosis, many kinds of hydrogel have been fabricated to eliminate infections with pathogens. The unique properties of hydrogels make them ideally suited to wound dressings because they provide a moist environment for wound healing and act as a barrier against bacteria. This review article will mainly cover the recent developments and innovations of antibacterial hydrogels for diabetic chronic wound healing.Graphical Abstract: Keywords: antibacterial, hydrogel, diabetic chronic wound, infection, inflammation, wound dressing
