Nestin Expression Is Associated with Relapses in Head and Neck Lesions
Mario Pérez-Sayáns,
Cintia M Chamorro-Petronacci,
Fátima Baltazar,
Fabio Ramoa Pires,
Ángel Ínsua,
Juan A Suárez-Quintanilla,
José M Suárez-Peñaranda
Affiliations
Mario Pérez-Sayáns
Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes), Faculty of Medicine and Dentistry, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
Cintia M Chamorro-Petronacci
Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain
Fátima Baltazar
Life and Health Science Research Institute (ICVS), School of Medicine University of Minho, 4710-057 Braga, Portugal
Fabio Ramoa Pires
Post-Graduation Program in Dentistry, Department of Oral Pathology, Estácio de Sá University, State University of Rio de Janeiro, Rio de Janeiro 22631-000, Brazil
Ángel Ínsua
Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, MI 48109-1078, USA
Juan A Suárez-Quintanilla
Area of Human Anatomy and Embryology, Faculty of Medicine and Dentistry, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
José M Suárez-Peñaranda
Pathological Anatomy Service, University Hospital Complex of Santiago (CHUS), 15706 Santiago de Compostela, Spain
Background: The aim was to investigate the clinical significance of nestin immunohistochemical expression in head and neck area lesions and to study its role in patient survival and recurrence. Methods: 39 (44.3%) nasosinus, 37 (42%) major salivary gland (6 submandibular and 31 parotid) and 12 (13.6%) oral cavity lesions of paraffin-embedded samples were retrospectively included. Results: The expression was categorized into grades, negative for 55 (62.5%) cases, grade 1 in 10 cases (11.4%), grade 2 in 12 cases (13.6%), and grade 3 in 11 cases (12.5%); 100% of pleomorphic adenomas were positive for nestin with grade 3 intensity, 100% of polyps and inverted papillomas were negative (p p = 0.002). ROC (receiver operating characteristic) curves revealed that the positivity for nestin (+/−) in relation to malignancy, presented a sensitivity of 50.98%, a specificity of 81.08%, with an area under the curve of 0.667 (p = 0.009). Conclusions: Nestin could be a useful marker to detect the presence of stem cells in head and neck tumors that have a role in tumor initiation and progression.
