Nature Communications (Dec 2022)
A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice
- Carl-Philipp Hackstein,
- Dana Costigan,
- Linnea Drexhage,
- Claire Pearson,
- Samuel Bullers,
- Nicholas Ilott,
- Hossain Delowar Akther,
- Yisu Gu,
- Michael E. B. FitzPatrick,
- Oliver J. Harrison,
- Lucy C. Garner,
- Elizabeth H. Mann,
- Sumeet Pandey,
- Matthias Friedrich,
- Nicholas M. Provine,
- Holm H. Uhlig,
- Emanuele Marchi,
- Fiona Powrie,
- Paul Klenerman,
- Emily E. Thornton
Affiliations
- Carl-Philipp Hackstein
- Peter Medawar Building for Pathogen Research, University of Oxford
- Dana Costigan
- MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Linnea Drexhage
- Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford
- Claire Pearson
- Kennedy Institute of Rheumatology, NDORMS, University of Oxford
- Samuel Bullers
- Kennedy Institute of Rheumatology, NDORMS, University of Oxford
- Nicholas Ilott
- Kennedy Institute of Rheumatology, NDORMS, University of Oxford
- Hossain Delowar Akther
- Peter Medawar Building for Pathogen Research, University of Oxford
- Yisu Gu
- Kennedy Institute of Rheumatology, NDORMS, University of Oxford
- Michael E. B. FitzPatrick
- Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford
- Oliver J. Harrison
- Center for Fundamental Immunology, Benaroya Research Institute
- Lucy C. Garner
- Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford
- Elizabeth H. Mann
- Kennedy Institute of Rheumatology, NDORMS, University of Oxford
- Sumeet Pandey
- Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford
- Matthias Friedrich
- Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford
- Nicholas M. Provine
- Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford
- Holm H. Uhlig
- Translational Gastroenterology Unit, and Biomedical Research Centre, and Department of Paediatrics, University of Oxford
- Emanuele Marchi
- Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford
- Fiona Powrie
- Kennedy Institute of Rheumatology, NDORMS, University of Oxford
- Paul Klenerman
- Peter Medawar Building for Pathogen Research, University of Oxford
- Emily E. Thornton
- MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-022-35126-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Interactions between the host immune response and the commensal microbiota play essential roles in health and disease. Here the authors identify a population of MHC class II, innate like, commensal reactive cells in the gut of mice and humans.
