Graphene oxide enhances SBA-15 ability towards preconcentration as well as determination of barbiturate drug in real samples

Abstract

In this study, a simple, sensitive, and high performance method was employed to extract and preconcentration of trace amount of sodium barbiturate drug by using mesoporous silica (SBA-15) modified by graphene oxide (GO). TEM, BET, TGA, FE-SEM, EDS, and elemental analysis CHN were used to characterization of mesoporous SBA-15 and nanocomposite. Effective parameters in barbiturate extraction such as pH, amount of nanocomposite, eluent type, contacting time, ionic power of solution, and sample volume were optimized for quantitative determination of barbiturate. Analytical figures of merit such as accuracy, limit of detection, preconcentration and enrichment factors were calculated and proved the suitability of our proposed method. Calibration curve shows linear correlation in 50-2000 ng mL-1 with detection limit of 17 ng mL-1. The relative standard deviation (n=10) was 1.39% and the preconcentration factor was 50 using 100 mL of sample.

Keywords

• SBA-15 nanocomposite
• Graphene oxide
• Sodium barbiturate
• Preconcentration
• Drug delivery