Antioxidants
(Jun 2023)
Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice
Maria Clara Barbosa-de-Oliveira,
Paolo Oliveira-Melo,
Marcos Henrique Gonçalves da Silva,
Flávio Santos da Silva,
Felipe Andrade Carvalho da Silva,
Bruno Vinicios Silva de Araujo,
Moacir Franco de Oliveira,
Aristides Tadeu Correia,
Sidnei Miyoshi Sakamoto,
Samuel Santos Valença,
Manuella Lanzetti,
Martina Schmidt,
Emanuel Kennedy-Feitosa
Affiliations
Maria Clara Barbosa-de-Oliveira
Morphophysiopharmacology Laboratory, Department of Health Sciences, Federal University of the Semi-Arid Region, Mossoró 59625-900, Brazil
Paolo Oliveira-Melo
Laboratório de Pesquisa em Cirurgia Torácica, Faculdade de Medicina HCFMUSP, Universidade de Sao Paulo, Sao Paulo 05508-220, Brazil
Marcos Henrique Gonçalves da Silva
Department of Clinical Medicine, Federal Fluminense University (UFF), Niterói 24000-000, Brazil
Flávio Santos da Silva
Morphophysiopharmacology Laboratory, Department of Health Sciences, Federal University of the Semi-Arid Region, Mossoró 59625-900, Brazil
Felipe Andrade Carvalho da Silva
Morphophysiopharmacology Laboratory, Department of Health Sciences, Federal University of the Semi-Arid Region, Mossoró 59625-900, Brazil
Bruno Vinicios Silva de Araujo
Morphophysiopharmacology Laboratory, Department of Health Sciences, Federal University of the Semi-Arid Region, Mossoró 59625-900, Brazil
Moacir Franco de Oliveira
Department of Animal Science, Federal University of the Semi-Arid Region, Mossoró 59625-900, Brazil
Aristides Tadeu Correia
Laboratório de Pesquisa em Cirurgia Torácica, Faculdade de Medicina HCFMUSP, Universidade de Sao Paulo, Sao Paulo 05508-220, Brazil
Sidnei Miyoshi Sakamoto
Morphophysiopharmacology Laboratory, Department of Health Sciences, Federal University of the Semi-Arid Region, Mossoró 59625-900, Brazil
Samuel Santos Valença
Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-590, Brazil
Manuella Lanzetti
Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-590, Brazil
Martina Schmidt
Department of Molecular Pharmacology, University of Groningen, Antonius Deusinglaan 1, Building 3211, Room 406, 9713 AV Groningen, The Netherlands
Emanuel Kennedy-Feitosa
Morphophysiopharmacology Laboratory, Department of Health Sciences, Federal University of the Semi-Arid Region, Mossoró 59625-900, Brazil
DOI
https://doi.org/10.3390/antiox12061258
Journal volume & issue
Vol. 12,
no. 6
Abstract
Read online
This study investigates the role of eugenol (EUG) on CS-induced acute lung injury (ALI) and how this compound is able to modulate macrophage activity. C57BL/6 mice were exposed to 12 cigarettes/day/5days and treated 15 min/day/5days with EUG. Rat alveolar macrophages (RAMs) were exposed to CSE (5%) and treated with EUG. In vivo, EUG reduced morphological changes inflammatory cells, oxidative stress markers, while, in vitro, it induced balance in the oxidative stress and reduced the pro-inflammatory cytokine release while increasing the anti-inflammatory one. These results suggest that eugenol reduced CS-induced ALI and acted as a modulator of macrophage activity.
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