Early Progression of Aortic Stenosis Associated With Iatrogenic Variant Transthyretin Amyloidosis After Domino Liver Transplantation

Yasuhito Hosoda, MD; Mitsuharu Ueda, MD, PhD; Jun Takaki, MD; Ken Okamoto, MD, PhD; Taro Yamashita, MD, PhD; Toshihiro Fukui, MD, PhD

JACC: Case Reports (Jul 2020)

Early Progression of Aortic Stenosis Associated With Iatrogenic Variant Transthyretin Amyloidosis After Domino Liver Transplantation

Yasuhito Hosoda, MD,
Mitsuharu Ueda, MD, PhD,
Jun Takaki, MD,
Ken Okamoto, MD, PhD,
Taro Yamashita, MD, PhD,
Toshihiro Fukui, MD, PhD

Affiliations

Yasuhito Hosoda, MD: Department of Cardiovascular Surgery, Kumamoto University Hospital, Kumamoto, Japan
Mitsuharu Ueda, MD, PhD: Department of Neurology, Kumamoto University Hospital, Kumamoto, Japan; Amyloidosis Center, Kumamoto University Hospital, Kumamoto, Japan
Jun Takaki, MD: Department of Cardiovascular Surgery, Kumamoto University Hospital, Kumamoto, Japan
Ken Okamoto, MD, PhD: Department of Cardiovascular Surgery, Kumamoto University Hospital, Kumamoto, Japan
Taro Yamashita, MD, PhD: Department of Neurology, Kumamoto University Hospital, Kumamoto, Japan; Amyloidosis Center, Kumamoto University Hospital, Kumamoto, Japan
Toshihiro Fukui, MD, PhD: Department of Cardiovascular Surgery, Kumamoto University Hospital, Kumamoto, Japan; Address for correspondence: Dr. Toshihiro Fukui, Department of Cardiovascular Surgery, Kumamoto University Hospital, 1-1-1 Honjo, Kumamoto 860-8556, Japan.

Journal volume & issue: Vol. 2, no. 8
pp. 1155 – 1160

Abstract

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We report a 65-year-old man who underwent aortic valve replacement because of severe aortic stenosis associated with de novo iatrogenic variant transthyretin amyloidosis derived from a liver graft extracted from a patient with hereditary transthyretin amyloidosis 9 years after the domino liver transplantation. (Level of Difficulty: Advanced.)

Published in JACC: Case Reports

ISSN: 2666-0849 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-case-reports

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