Human Chorionic Gonadotropin in the Regulation of T-Helpers Type 17

Abstract

Chorionic gonadotropin (hCG) is a key pregnancy hormone that regulates steroidogenesis and has immunomodulatory activity. We studied the effects of native and recombinant hCG on the differentiation, proliferation, and production of IL-17 and IFN-ɣ by T-helper cells induced into the phenotype of T-helper type 17 (Th17) in vitro. We found that hCG had no significant effects on the level of Th17 cells, as assessed by RORɣτ expression, and the proliferation of these cells (Ki-67+). In addition, no effects of hCG on the production of IL-17 and IFN-ɣ by T-helpers induced in the Th17 phenotype were found. At the same time, recombinant hCG (100 IU/mL) increased the number of non-Th17 T-helpers (RORγt-Ki-67+). Thus, hCG did not modulate Th17 cells in our experimental model.