Symposium 13: Impact of prediabetes on macrovascular disease

Abstract

Macrovascular complications are often present at the time of diagnosis of type 2 diabetes: in a retrospective study that included 159,736 people newly diagnosed with diabetes, 23.5% had at least one macrovascular complication (coronary, cerebrovascular, and/or peripheral arterial disease)1. Epidemiological studies have shown that prediabetes is a strong predictor of cardiovascular disease (CVD). In a meta-analysis including 53 prospective cohort studies with 1,611,339 individuals, with a follow-up of 9.5 years, prediabetes was associated with an increased risk of CVD, coronary heart disease, stroke and all-cause mortality compared with normoglycemia2. In this sense, the EPIC-Norfolk study showed that a 1% increase in HbA1c within the normal range was associated with greater cardiovascular mortality at ten years3.

Keywords

• diabetes mellitus
• enfermedad macrovascular