Bioinspired total synthesis of katsumadain A by organocatalytic enantioselective 1,4-conjugate addition

Abstract

Katsumadain A, a naturally occurring influenza virus neuraminidase (NA) inhibitor, was synthesized by using a bioinspired, organocatalytic enantioselective 1,4-conjugate addition of styryl-2-pyranone with cinnamaldehyde, followed by a tandem Horner–Wadsworth–Emmons/oxa Michael addition.

Keywords

• bioinspired synthesis
• catalysis
• katsumadain A
• natural product
• organocatalytic 1,4-conjugate addition