The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation

Bing Liu; Oscar C. Salgado; Sangya Singh; Keli L. Hippen; Jason C. Maynard; Alma L. Burlingame; Lauren E. Ball; Bruce R. Blazar; Michael A. Farrar; Kristin A. Hogquist; Hai-Bin Ruan

doi:10.1038/s41467-019-08300-3

Nature Communications (Jan 2019)

The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation

Bing Liu,
Oscar C. Salgado,
Sangya Singh,
Keli L. Hippen,
Jason C. Maynard,
Alma L. Burlingame,
Lauren E. Ball,
Bruce R. Blazar,
Michael A. Farrar,
Kristin A. Hogquist,
Hai-Bin Ruan

Affiliations

Bing Liu: Department of Integrative Biology and Physiology, University of Minnesota
Oscar C. Salgado: Center for Immunology, University of Minnesota
Sangya Singh: Division of Blood and Marrow Transplantation, Cancer Center and the Department of Pediatrics, University of Minnesota
Keli L. Hippen: Division of Blood and Marrow Transplantation, Cancer Center and the Department of Pediatrics, University of Minnesota
Jason C. Maynard: Department of Pharmaceutical Chemistry, University of California, San Francisco
Alma L. Burlingame: Department of Pharmaceutical Chemistry, University of California, San Francisco
Lauren E. Ball: Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina
Bruce R. Blazar: Division of Blood and Marrow Transplantation, Cancer Center and the Department of Pediatrics, University of Minnesota
Michael A. Farrar: Center for Immunology, University of Minnesota
Kristin A. Hogquist: Center for Immunology, University of Minnesota
Hai-Bin Ruan: Department of Integrative Biology and Physiology, University of Minnesota

DOI: https://doi.org/10.1038/s41467-019-08300-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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The transcription factor Foxp3 and Stat5 modulate lineage stability and function of regulatory T (Treg) cells to promote immune homeostasis. Here the authors show that O-GlcNAcylation of Foxp3 and Stat5, mediated by O-GlcNAc transferase (OGT), is essential for Treg-mediate immune balance, with Treg-specific deficiency of OGT leading to severe autoimmunity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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