Super-enhancer-guided mapping of regulatory networks controlling mouse trophoblast stem cells

Bum-Kyu Lee; Yu jin Jang; Mijeong Kim; Lucy LeBlanc; Catherine Rhee; Jiwoon Lee; Samuel Beck; Wenwen Shen; Jonghwan Kim

doi:10.1038/s41467-019-12720-6

Nature Communications (Oct 2019)

Super-enhancer-guided mapping of regulatory networks controlling mouse trophoblast stem cells

Bum-Kyu Lee,
Yu jin Jang,
Mijeong Kim,
Lucy LeBlanc,
Catherine Rhee,
Jiwoon Lee,
Samuel Beck,
Wenwen Shen,
Jonghwan Kim

Affiliations

Bum-Kyu Lee: Department of Molecular Biosciences, The University of Texas at Austin
Yu jin Jang: Department of Molecular Biosciences, The University of Texas at Austin
Mijeong Kim: Department of Molecular Biosciences, The University of Texas at Austin
Lucy LeBlanc: Department of Molecular Biosciences, The University of Texas at Austin
Catherine Rhee: Department of Molecular Biosciences, The University of Texas at Austin
Jiwoon Lee: Department of Molecular Biosciences, The University of Texas at Austin
Samuel Beck: Department of Molecular Biosciences, The University of Texas at Austin
Wenwen Shen: Department of Molecular Biosciences, The University of Texas at Austin
Jonghwan Kim: Department of Molecular Biosciences, The University of Texas at Austin

DOI: https://doi.org/10.1038/s41467-019-12720-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

Read online

Trophectoderm lineage development is essential for implantation, placentation, and healthy pregnancy. Here the authors map super-enhancers (SEs) in trophoblast stem cells and find both TE-specific master regulators and 150 previous uncharacterised transcription factors that are SE-associated, providing insight into trophectoderm-specific regulatory networks.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal