Nature Communications (Feb 2020)
c-FLIP is crucial for IL-7/IL-15-dependent NKp46+ ILC development and protection from intestinal inflammation in mice
- Ute Bank,
- Katrin Deiser,
- Carlos Plaza-Sirvent,
- Lisa Osbelt,
- Amelie Witte,
- Laura Knop,
- Rebecca Labrenz,
- Robert Jänsch,
- Felix Richter,
- Aindrila Biswas,
- Ana C. Zenclussen,
- Eric Vivier,
- Chiara Romagnani,
- Anja A. Kühl,
- Ildiko R. Dunay,
- Till Strowig,
- Ingo Schmitz,
- Thomas Schüler
Affiliations
- Ute Bank
- Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University
- Katrin Deiser
- Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University
- Carlos Plaza-Sirvent
- Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University
- Lisa Osbelt
- Institute of Medical Microbiology and Hospital Hygiene, Medical Faculty, Otto-von-Guericke University
- Amelie Witte
- Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University
- Laura Knop
- Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University
- Rebecca Labrenz
- Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University
- Robert Jänsch
- Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University
- Felix Richter
- Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University
- Aindrila Biswas
- Institute of Inflammation and Neurodegeneration, Medical Faculty, Otto-von-Guericke University
- Ana C. Zenclussen
- Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University
- Eric Vivier
- Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université, Inserm, CNRS
- Chiara Romagnani
- Innate Immunity, German Rheumatism Research Center (DRFZ), Leibniz Association
- Anja A. Kühl
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, iPATH
- Ildiko R. Dunay
- Institute of Inflammation and Neurodegeneration, Medical Faculty, Otto-von-Guericke University
- Till Strowig
- Microbial Immune Regulation Research Group, Helmholtz Centre for Infection Research
- Ingo Schmitz
- Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University
- Thomas Schüler
- Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University
- DOI
- https://doi.org/10.1038/s41467-020-14782-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
Innate lymphoid cells (ILC) are important immune cells for maintaining the gut homeostasis. Here the authors show that c-FLIP, an anti-apoptotic molecule, is important for the development of NKP46+ ILC1, including conventional natural killer (cNK) cells, and ILC3, with cNK being more critical for ameliorating intestinal inflammation.
