Nature Communications (May 2020)

A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism

  • J. J. David Ho,
  • Nathan C. Balukoff,
  • Phaedra R. Theodoridis,
  • Miling Wang,
  • Jonathan R. Krieger,
  • Jonathan H. Schatz,
  • Stephen Lee

DOI
https://doi.org/10.1038/s41467-020-16504-1
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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mRNA translation efficiency is regulated in response to stimuli. Here the authors employ mass spectrometry analysis of ribosome fractions and show that under hypoxia, oxygen-sensitive RNA binding proteins enhance the translation efficiency of glycolysis pathway transcripts.