Generation of a human iPSC line CIBi008-A from amniotic fluid-derived cells of a fetus with β-thalassemia carrying variants of −28A > G and IVS-II-654C > T in HBB

Abstract

β-thalassemia is mostly caused by homozygous or compound heterozygous variants in HBB. We generated a human iPSC line CIBi008-A from amniotic fluid-derived cells of a fetus with β-thalassemia major, carrying compound heterozygous −28A > G and IVS-II-654C > T variants in HBB gene. This line will be a valuable resource for disease modeling and testing gene therapies for β-thalassemia.