Macrophage pyroptosis and its crucial role in ALI/ARDS

Yuju Cai; Yuju Cai; Luorui Shang; Fangyuan Zhou; Mengqi Zhang; Jinxiao Li; Shuhan Wang; Qifeng Lin; Jianghua Huang; Shenglan Yang

doi:10.3389/fimmu.2025.1530849

Frontiers in Immunology (Feb 2025)

Macrophage pyroptosis and its crucial role in ALI/ARDS

Yuju Cai,
Yuju Cai,
Luorui Shang,
Fangyuan Zhou,
Mengqi Zhang,
Jinxiao Li,
Shuhan Wang,
Qifeng Lin,
Jianghua Huang,
Shenglan Yang

Affiliations

Yuju Cai: Department of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Yuju Cai: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Luorui Shang: Department of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Fangyuan Zhou: Department of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Mengqi Zhang: Department of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Jinxiao Li: Department of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Shuhan Wang: Department of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Qifeng Lin: Department of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Jianghua Huang: Department of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Shenglan Yang: Department of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

DOI: https://doi.org/10.3389/fimmu.2025.1530849
Journal volume & issue: Vol. 16

Abstract

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Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS) is a severe clinical syndrome characterized by high morbidity and mortality, primarily due to lung injury. However, the pathogenesis of ALI/ARDS remains a complex issue. In recent years, the role of macrophage pyroptosis in lung injury has garnered extensive attention worldwide. This paper reviews the mechanism of macrophage pyroptosis, discusses its role in ALI/ARDS, and introduces several drugs and intervening measures that can regulate macrophage pyroptosis to influence the progression of ALI/ARDS. By doing so, we aim to enhance the understanding of the mechanism of macrophage pyroptosis in ALI/ARDS and provide novel insights for its treatment.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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Abstract

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