Microglial activation increases cocaine self-administration following adolescent nicotine exposure

K. E. Linker; M. G. Elabd; P. Tawadrous; M. Cano; K. N. Green; M. A. Wood; F. M. Leslie

doi:10.1038/s41467-019-14173-3

Nature Communications (Jan 2020)

Microglial activation increases cocaine self-administration following adolescent nicotine exposure

K. E. Linker,
M. G. Elabd,
P. Tawadrous,
M. Cano,
K. N. Green,
M. A. Wood,
F. M. Leslie

Affiliations

K. E. Linker: Department of Anatomy and Neurobiology, University of California Irvine
M. G. Elabd: Department of Anatomy and Neurobiology, University of California Irvine
P. Tawadrous: Department of Anatomy and Neurobiology, University of California Irvine
M. Cano: Department of Anatomy and Neurobiology, University of California Irvine
K. N. Green: Department of Neurobiology and Behavior, University of California Irvine
M. A. Wood: Department of Neurobiology and Behavior, University of California Irvine
F. M. Leslie: Department of Anatomy and Neurobiology, University of California Irvine

DOI: https://doi.org/10.1038/s41467-019-14173-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Adolescents are particularly sensitive to nicotine. Here the authors show that in mice, microglial activation contributes to the enhanced sensitivity to cocaine caused by nicotine exposure in young mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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