THERAPEUTIC DRUG MONITORING OF LAMOTRIGINE: DEVELOPMENT OF PHARMACOKINETIC APPROACHES AIMING AT THE INDIVIDUAL-BASED ANTICONVULSIVE PHARMACOTHERAPY

Abstract

Abstract: this paper presents the results of therapeutic drug monitoring of lamotrigine, an anticonvulsant epilepsy medication, in patients with cryptogenic focal epilepsy using plasma and saliva as a biological material for drug testing. Comparative analysis of the steady-state plasma and saliva lamotrigine concentrations (СssMIN and СssMAX) allows the conclusion that saliva can be used as a suitable biological substrate for therapeutic drug monitoring.

Keywords

• therapeutic drug monitoring (tdm)
• lamotrigine
• pharmacokinetics
• anticonvulsants
• steady-state concentrations (сss)
• plasma
• saliva