Frontiers in Cardiovascular Medicine (Mar 2022)

Dilated Left Ventricular End-Diastolic Diameter Is a New Risk Factor of Acute Kidney Injury Following Coronary Angiography

  • Qiang Li,
  • Qiang Li,
  • Shiqun Chen,
  • Shiqun Chen,
  • Haozhang Huang,
  • Haozhang Huang,
  • Weihua Chen,
  • Liwei Liu,
  • Liwei Liu,
  • Bo Wang,
  • Bo Wang,
  • Wenguang Lai,
  • Shixin Yi,
  • Shixin Yi,
  • Ming Ying,
  • Ming Ying,
  • Ronghui Tang,
  • Zhidong Huang,
  • Zhidong Huang,
  • Jiayi Deng,
  • Jiyan Chen,
  • Jiyan Chen,
  • Jiyan Chen,
  • Jin Liu,
  • Jin Liu,
  • Yong Liu,
  • Yong Liu,
  • Yong Liu

DOI
https://doi.org/10.3389/fcvm.2022.827524
Journal volume & issue
Vol. 9

Abstract

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PurposeLeft ventricular end-diastolic diameter (LVEDD) is a common indicator in echocardiogram, and dilated LVEDD was correlated with left ventricular insufficiency. However, it is uncertain whether dilated LVEDD is associated with increasing the risk of contrast-associated acute kidney injury (CA-AKI) in patients with coronary artery disease (CAD).Patients and MethodsWe enrolled 8,189 patients with CAD undergoing coronary angiography (CAG) between January 2007 and December 2018. Patients were divided into two groups according to the LVEDD length (normal LVEDD: men: LVEDD ≤56 mm, women: LVEDD ≤51 mm; dilated LVEDD: men: LVEDD >56 mm, women: LVEDD >51 mm). The endpoints were CA-AKI0350 and CA-AKI0525 (CA-AKI0350: an increase in the serum creatinine (Scr) level by >0.3 mg/dl or >50% within the first 48 h after CAG; CA-AKI0525: an absolute Scr increase ≥ 0.5 mg/dl or a relative increase ≥ 25% within 72 h after contrast medium exposure). In-hospital dialysis, 30-day mortality, and 1-year mortality were contained as well. Univariate and multivariable logistic regressions were used to assess the association between LVEDD and CA-AKI.ResultsAmong 8,189 participants (men: 76.6%, mean age: 64.4 ± 10.7 years), 1,603 (19.6%) presented with dilated LVEDD. In addition, the dilated LVEDD group indicated an elevation of CA-AKI0350 (12.4 vs. 6.2%, p < 0.001) and CA-AKI0525 (15.0 vs. 8.8%; p < 0.001) when compared with the normal group. According to multivariable logistic analysis, dilated LVEDD was an independent predictor of CA-AKI0350 [adjusted odds ratio (aOR): 1.31; 95% confidence interval (CI): 1.06–1.61, p = 0.010) and CA-AKI0525 (aOR: 1.32; 95% CI: 1.04–1.67; p = 0.020).ConclusionIn conclusion, these results demonstrated that the dilated LVEDD was a significant and independent predictor of CA-AKI following CAG in patients with CAD. Further verifications are needed to verify the association between LVEDD and CA-AKI.

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