Hormone secreted by the pineal gland - melatonin feedsideward involvement in cancer growth

Abstract

Here the presence of a chronomodulating actions of melatonin via feedsideawards mechanism in vitro as well as, in vivo, in two experimental models was presented. Intriguing process of how this takes place may due to an interacting pineal pituitary-adrenal networks (1). In vivo studies confirmed the role of melatonin in the study on Meth-A-sarcoma in mice and in LOU tumor growth. Melatonin disrupted circadian time structure of in vivo tumor growth on a feedsideawards manner in the case of the immunocytoma growth in female inoculated rats. Low doses disrupted the circadian DNA synthesis of mF-cells. Drug delivery systems must be taken in consideration the role of melatonin feedsideawards involvement during chronomodulated therapy of cancer patients.

Keywords

• мелатонин
• хрономодулирующее действие
• эпифиз-гипоталламо-надпочечниковая система
• опухоль Louvain
• опухоли нейроэндокринной системы
• циркадианный ритм синтеза ДНК