Acta Cirúrgica Brasileira (Jan 2016)

Adjunctive Hyperbaric Oxygen Therapy promotes successful healing in patients with refractory Crohn's disease

  • Marley Ribeiro Feitosa,
  • Omar Féres Filho,
  • Camila Mussolin Tamaki,
  • Camila Perazzoli,
  • Mário Vinícius Angelete Alvarez Bernardes,
  • Rogério Serafim Parra,
  • José Joaquim Ribeiro da Rocha,
  • Omar Féres

DOI
https://doi.org/10.1590/S0102-86502016001300005
Journal volume & issue
Vol. 31, no. suppl 1
pp. 19 – 23

Abstract

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PURPOSE: To investigate de adjunctive effect of Hyperbaric Oxygen Therapy in a group of patients with refractory Crohn's disease. METHODS: A total of 29 subjects with refractory Crohn's disease were submitted to daily sessions of Hyperbaric Oxygen Therapy, in a 2800 Sechrist Monoplace Hyperbaric Chamber (Sechrist, USA) pressurized to 2.4 ATA. Each session lasted 2 hours. The endpoint was closure of enterocutaneous fistulas and complete healing of Pyoderma Gangrenosum and perineal Crohn's disease. RESULTS: A total of 829 HBOT sessions were performed and no complications were noted. Overall success rate was 76% (22 cases). Pyoderma Gangrenosum and enterocutaneous fistulas had the highest successful healing rates (100% and 91%, respectively). Perineal Crohn's disease healing rate was 65%. CONCLUSION: Adjunctive Hyperbaric Oxygen Therapy promoted satisfactory healing in a group of patients with refractory Crohn's disease.

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