Treatment of mild onychomycosis with naftifine ketoconazole cream and ultra-pulse CO2 laser after occlusion and nail scraping

Abstract

Objective: To observe the efficacy of naftifine ketoconazole cream in combination with ultra-pulse CO2 laser after occlusion and nail scraping for mild onychomycosis. Methods: A total of 55 patients with mild onychomycosis were randomly divided into the treatment (27 cases, 58 nails) and the control groups (28 cases, 61 nails). Both groups were treated with topical naftifine ketoconazole cream twice daily after occlusion and nail scraping. The treatment group was also treated with ultra-pulse CO2 laser once weekly. The therapeutic effects were compared after 12-week treatments. Results: Fifty five nails were cured and 3 nails were markedly improved in the treatment group. In the control group, 39 nails were cured and 11 nails were markedly improved, while some improvement and no effect were found in 9 nails and 2 nails, respectively. The therapeutic efficacy significantly differed between these two groups (χ2=9.48, P<0.05). Conclusion: Following occlusion and nail scraping, topical naftifine ketoconazole cream in combination with ultra-pulse CO2 laser is effective and safe for mild onychomycosis.

Keywords

• ultra-pulse co2 laser
• onychomycosis
• occlusive dressing