Nature Communications (Apr 2022)
Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses
- Javier Rodríguez-Ubreva,
- Anna Arutyunyan,
- Marc Jan Bonder,
- Lucía Del Pino-Molina,
- Stephen J. Clark,
- Carlos de la Calle-Fabregat,
- Luz Garcia-Alonso,
- Louis-François Handfield,
- Laura Ciudad,
- Eduardo Andrés-León,
- Felix Krueger,
- Francesc Català-Moll,
- Virginia C. Rodríguez-Cortez,
- Krzysztof Polanski,
- Lira Mamanova,
- Stijn van Dongen,
- Vladimir Yu. Kiselev,
- María T. Martínez-Saavedra,
- Holger Heyn,
- Javier Martín,
- Klaus Warnatz,
- Eduardo López-Granados,
- Carlos Rodríguez-Gallego,
- Oliver Stegle,
- Gavin Kelsey,
- Roser Vento-Tormo,
- Esteban Ballestar
Affiliations
- Javier Rodríguez-Ubreva
- Epigenetics and Immune Disease Group, Josep Carreras Research Institute (IJC), Badalona
- Anna Arutyunyan
- Cellular Genetics Department, Wellcome Sanger Institute, Wellcome Genome Campus
- Marc Jan Bonder
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus
- Lucía Del Pino-Molina
- Clinical Immunology Department, La Paz University Hospital and Lymphocyte Pathophysiology in Immunodeficiencies Group, La Paz Institute for Health Research (IdiPAZ), Center for Biomedical Network Research on Rare Diseases (CIBERER U767)
- Stephen J. Clark
- Epigenetics Programme, Babraham Institute
- Carlos de la Calle-Fabregat
- Epigenetics and Immune Disease Group, Josep Carreras Research Institute (IJC), Badalona
- Luz Garcia-Alonso
- Cellular Genetics Department, Wellcome Sanger Institute, Wellcome Genome Campus
- Louis-François Handfield
- Cellular Genetics Department, Wellcome Sanger Institute, Wellcome Genome Campus
- Laura Ciudad
- Epigenetics and Immune Disease Group, Josep Carreras Research Institute (IJC), Badalona
- Eduardo Andrés-León
- Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas (IPBLN-CSIC)
- Felix Krueger
- Bioinformatics Unit, Babraham Institute
- Francesc Català-Moll
- Epigenetics and Immune Disease Group, Josep Carreras Research Institute (IJC), Badalona
- Virginia C. Rodríguez-Cortez
- Chromatin and Disease Group, Cancer Epigenetics and Biology Programme (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat
- Krzysztof Polanski
- Cellular Genetics Department, Wellcome Sanger Institute, Wellcome Genome Campus
- Lira Mamanova
- Cellular Genetics Department, Wellcome Sanger Institute, Wellcome Genome Campus
- Stijn van Dongen
- Cellular Genetics Department, Wellcome Sanger Institute, Wellcome Genome Campus
- Vladimir Yu. Kiselev
- Cellular Genetics Department, Wellcome Sanger Institute, Wellcome Genome Campus
- María T. Martínez-Saavedra
- Department of Immunology, Hospital Universitario de Gran Canaria Dr Negrín
- Holger Heyn
- CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST)
- Javier Martín
- Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas (IPBLN-CSIC)
- Klaus Warnatz
- Faculty of Medicine, Department of Rheumatology and Clinical Immunology, Medical Center, University of Freiburg
- Eduardo López-Granados
- Clinical Immunology Department, La Paz University Hospital and Lymphocyte Pathophysiology in Immunodeficiencies Group, La Paz Institute for Health Research (IdiPAZ), Center for Biomedical Network Research on Rare Diseases (CIBERER U767)
- Carlos Rodríguez-Gallego
- Department of Immunology, Hospital Universitario de Gran Canaria Dr Negrín
- Oliver Stegle
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus
- Gavin Kelsey
- Centre for Trophoblast Research, University of Cambridge
- Roser Vento-Tormo
- Cellular Genetics Department, Wellcome Sanger Institute, Wellcome Genome Campus
- Esteban Ballestar
- Epigenetics and Immune Disease Group, Josep Carreras Research Institute (IJC), Badalona
- DOI
- https://doi.org/10.1038/s41467-022-29450-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Common variable immunodeficiency (CVID) is the most prevalent primary immunodeficiency. Here the authors perform single-cell omics analyses in CVID-discordant monozygotic twins and show epigenetic and transcriptional alterations associated with activation in memory B cells.
