Progress on the mechanism of action of emodin against breast cancer cells
Ruoqing Chen,
Hairong Zhang,
Xue Zhao,
Lin Zhu,
XiaoYu Zhang,
Yuning Ma,
Lei Xia
Affiliations
Ruoqing Chen
School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR China
Hairong Zhang
Department of Obstetrics and Gynecology, Shandong Provincial Third Hospital, Shandong University, Jinan, 250031, PR China
Xue Zhao
School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR China
Lin Zhu
School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR China
XiaoYu Zhang
School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR China
Yuning Ma
School of Acupuncture-Moxibustion and Tuina, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR China; Corresponding author.
Lei Xia
Department of Pathology, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR China; Corresponding author. Department of Pathology, Shandong University of Traditional Chinese Medicine, 250031, Jinan, PR China.
At present, the role of active ingredients of traditional Chinese medicine in tumor therapy has gradually attracted people's attention, and anthraquinones, which are structurally similar to adriamycin and epirubicin, are one of the hotspots of research. Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a natural anthraquinone compound isolated from rhubarb, Polygonum cuspidatum, and aloe vera. In recent years, emodin has received widespread attention for its remarkable anti-tumor effects, and its anti-breast cancer effects are manifested as induction of apoptosis, inhibition of tumor cell proliferation, inhibition of invasion and metastasis of tumor cells, and anti-tumor drug resistance. Moreover, emodin can act against multiple types of breast cancer cells by acting on different targets. In this paper, we reviewed the latest research progress on the anti-breast cancer effects of emodin and its anti-tumor mechanism, to provide reference and information for the treatment of breast cancer and the development of anti-tumor drugs.
