Dynamics of changes in the content of proteoglycans in the tissues of the cerebellum of rats under the influence of hypokinesia

Abstract

The article reflects the dynamics of changes in the content of proteoglycans in preparations that were taken from the cerebellum of experimental animals after modeling hypokinesia. Laboratory animals were removed from the experiment at different time intervals (3, 7, 14, 21 and 30 days of simulated hypokinesia) to identify the dynamics of changes in proteoglycan content using histochemical studies. The experiment was carried out on laboratory rats of the Vistar breed. The animals were divided into two groups: control and experimental. All laboratory rats were kept under standard vivarium conditions. The experiment is based on the model of hypokinesia proposed by E. A. Kovalenko. Complex studies showed the dynamics of changes in the content of proteoglycans, which were not homogeneous at different stages of the experiment. However, despite the different trends in the dynamics of the content of various fractional components of proteoglycans, one can note a general trend towards a decrease in proteoglycans. This indicates a negative effect of hypokinesia on the productive function of cerebellar tissue in experimental animals.