Synthesis and antimicrobial activity of coumarin derivatives metal complexes: An in vitro evaluation

Abstract

Complexes of 3-[ {-(3’,4’-di methoxy phenyl) }-prop-2-enoyl]-4-hydroxy-6-methyl-2H-chromene-2-one with Cu(II), Ni(II), Fe(II), Co(II) and Mn(II) have been synthesized and characterized using elemental analysis, IR spectra and conductivity measurements. These studies revealed that they are having octahedral geometry of the type [ML2(H2O)2]. In vitro antimicrobial activity of all synthesized compounds and standard drugs have been evaluated against four strains of bacterial culture and one fungus, which includes two gram +ve bacterial culture and two gram -ve bacterial culture. The compounds show net enhancement in activity on coordination of metals with ligand but moderate activity as compared to standard drugs.

Keywords

• antimicrobial activity, coumarin, metal complexes ,structural study