mBio
(Feb 2021)
An Antibiotic-Impacted Microbiota Compromises the Development of Colonic Regulatory T Cells and Predisposes to Dysregulated Immune Responses
Xiaozhou Zhang,
Timothy C. Borbet,
Angela Fallegger,
Matthew F. Wipperman,
Martin J. Blaser,
Anne Müller
Affiliations
Xiaozhou Zhang
Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
Timothy C. Borbet
Department of Pathology, New York University School of Medicine, New York, New York, USA
Angela Fallegger
Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
Matthew F. Wipperman
Immunology Program, Sloan Kettering Institute, New York, USA
Martin J. Blaser
ORCiD
Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey, USA
Anne Müller
Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
DOI
https://doi.org/10.1128/mBio.03335-20
Journal volume & issue
Vol. 12,
no. 1
Abstract
Read online
The assembly of microbial communities that populate all mucosal surfaces of the human body begins right after birth. This process is prone to disruption as newborns and young infants are increasingly exposed to antibiotics, both deliberately for therapeutic purposes, and as a consequence of transmaternal exposure.
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