Visible-light Promoted Atom Transfer Radical Addition−Elimination (ATRE) Reaction for the Synthesis of Fluoroalkylated Alkenes Using DMA as Electron-donor
Wen-Wen Xu,
Le Wang,
Ting Mao,
Jiwei Gu,
Xiao-Fei Li,
Chun-Yang He
Affiliations
Wen-Wen Xu
Key Laboratory of Biocatalysis & Chiral Drug Synthesis of Guizhou Province, Generic Drug Research Center of Guizhou Province. School of Pharmacy, Zunyi Medical University, Zunyi 563003, China
Le Wang
Basic Medical School, Zunyi Medical University, Zunyi 563003, China
Ting Mao
Key Laboratory of Biocatalysis & Chiral Drug Synthesis of Guizhou Province, Generic Drug Research Center of Guizhou Province. School of Pharmacy, Zunyi Medical University, Zunyi 563003, China
Jiwei Gu
School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, United States
Xiao-Fei Li
Basic Medical School, Zunyi Medical University, Zunyi 563003, China
Chun-Yang He
Key Laboratory of Biocatalysis & Chiral Drug Synthesis of Guizhou Province, Generic Drug Research Center of Guizhou Province. School of Pharmacy, Zunyi Medical University, Zunyi 563003, China
Here, we describe a mild, catalyst-free and operationally-simple strategy for the direct fluoroalkylation of olefins driven by the photochemical activity of an electron donor−acceptor (EDA) complex between DMA and fluoroalkyl iodides. The significant advantages of this photochemical transformation are high efficiency, excellent functional group tolerance, and synthetic simplicity, thus providing a facile route for further application in pharmaceuticals and life sciences.
