Preparation and Evaluation of Bioactivity of Porous Bioglass Tablets for Bone Tissue Regeneration

Abstract

The present study endeavors in the preparation and characterization of semi crystalline 45S5 bioglass (BG) (SiO2-CaO-P2O5) through sol gel process. Dry press mold technique was used in the preparation porous BG tablets to examine the bioactivity through invitro studies. The synthesized BG powder was subjected to structural, morphological and mechanical characterization and the bioactivity was examined in vitro by immersing the BG tablet in the Simulated Body Fluid (SBF) solution. XRD pattern and the SEM micrographs revealed the semi crystalline nature of BG with spherical morphology. The elemental analysis confirms the presence of vital constituents required for Bone regeneration (Calcium, Phosphorous, Silica, and Sodium). The surface characterization of BG tablet reveals the pores structure of average pore size of 240nm which contributed to the high surface activity resulting in formation of carbonated hydroxy apatite (HCAP) when immersed in SBF. The disintegration studies denoted the stabilization period was after 48 of immersion of BG tablets in SBF solution. The compressive strength measurement of the tablet also reveals the higher mechanical stability.

Keywords

• sol-gel bioglass
• porous tablet
• bioactivity
• carbonated hydroxy apatite
• bone tissue regeneration
• mechanical stability.