Gain of chromosome region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma
Judith Dierlamm,
Eva M. Murga Penas,
Stefan Bentink,
Swen Wessendorf,
Hilmar Berger,
Michael Hummel,
Wolfram Klapper,
Dido Lenze,
Andreas Rosenwald,
Eugenia Haralambieva,
German Ott,
Sergio B. Cogliatti,
Peter Möller,
Carsten Schwaenen,
Harald Stein,
Markus Löffler,
Rainer Spang,
Lorenz Trümper,
Reiner Siebert,
for the Deutsche Krebshilfe Network Project “Molecular Mechanisms in Malignant Lymphomas”
Affiliations
Judith Dierlamm
Eva M. Murga Penas
Stefan Bentink
Swen Wessendorf
Hilmar Berger
Michael Hummel
Wolfram Klapper
Dido Lenze
Andreas Rosenwald
Eugenia Haralambieva
German Ott
Sergio B. Cogliatti
Peter Möller
Carsten Schwaenen
Harald Stein
Markus Löffler
Rainer Spang
Lorenz Trümper
Reiner Siebert
for the Deutsche Krebshilfe Network Project “Molecular Mechanisms in Malignant Lymphomas”
Background The aim of this study was to determine the impact of a gain of the MALT1 gene on gene expression and clinical parameters in diffuse large B-cell lymphoma.Design and Methods We analyzed 116 cases of diffuse large B-cell lymphoma by fluorescence in situ hybridization, array-based comparative genomic hybridization, and transcriptional profiling.Results A gain of 18q21 including MALT1 was detected in 44 cases (38%) and was accompanied by a gain of BCL2 in 43 cases. All cases with a 18q21/MALT1 gain showed BCL2 protein whereas 79% in the group without a 18q21/MALT1 gain did so (p
