Interchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiation

Matthew Antel; Romir Raj; Madona Y. G. Masoud; Ziwei Pan; Sheng Li; Barbara G. Mellone; Mayu Inaba

doi:10.1038/s41467-022-31737-y

Nature Communications (Jul 2022)

Interchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiation

Matthew Antel,
Romir Raj,
Madona Y. G. Masoud,
Ziwei Pan,
Sheng Li,
Barbara G. Mellone,
Mayu Inaba

Affiliations

Matthew Antel: Department of Cell Biology, University of Connecticut Health Center
Romir Raj: Department of Cell Biology, University of Connecticut Health Center
Madona Y. G. Masoud: Department of Cell Biology, University of Connecticut Health Center
Ziwei Pan: The Jackson Laboratory for Genomic Medicine
Sheng Li: The Jackson Laboratory for Genomic Medicine
Barbara G. Mellone: Department of Molecular and Cell Biology, University of Connecticut
Mayu Inaba: Department of Cell Biology, University of Connecticut Health Center

DOI: https://doi.org/10.1038/s41467-022-31737-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Asymmetric inheritance of organelles, proteins and RNAs occurs during stem cell division. Here the authors show the strength of pairing of homologous Stat92E loci, a stem cell-specific gene, changes immediately after the asymmetric division due to asymmetric inheritance of new histones to one of the daughter cells and is important for turning off gene expression in this cell as it differentiates.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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