Nature Communications (Oct 2019)
The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner
- Subramanya Srikantan,
- Yilun Deng,
- Zi-Ming Cheng,
- Anqi Luo,
- Yuejuan Qin,
- Qing Gao,
- Glaiza-Mae Sande-Docor,
- Sifan Tao,
- Xingyu Zhang,
- Nathan Harper,
- Chris E. Shannon,
- Marcel Fourcaudot,
- Zhi Li,
- Balakuntalam S. Kasinath,
- Stephen Harrison,
- Sunil Ahuja,
- Robert L. Reddick,
- Lily Q. Dong,
- Muhammad Abdul-Ghani,
- Luke Norton,
- Ricardo C. T. Aguiar,
- Patricia L. M. Dahia
Affiliations
- Subramanya Srikantan
- Division of Hematology and Medical Oncology, University of Texas Health Science Center at San Antonio (UTHSCSA)
- Yilun Deng
- Division of Hematology and Medical Oncology, University of Texas Health Science Center at San Antonio (UTHSCSA)
- Zi-Ming Cheng
- Division of Hematology and Medical Oncology, University of Texas Health Science Center at San Antonio (UTHSCSA)
- Anqi Luo
- Division of Hematology and Medical Oncology, University of Texas Health Science Center at San Antonio (UTHSCSA)
- Yuejuan Qin
- Division of Hematology and Medical Oncology, University of Texas Health Science Center at San Antonio (UTHSCSA)
- Qing Gao
- Division of Hematology and Medical Oncology, University of Texas Health Science Center at San Antonio (UTHSCSA)
- Glaiza-Mae Sande-Docor
- Division of Hematology and Medical Oncology, University of Texas Health Science Center at San Antonio (UTHSCSA)
- Sifan Tao
- Division of Hematology and Medical Oncology, University of Texas Health Science Center at San Antonio (UTHSCSA)
- Xingyu Zhang
- Division of Hematology and Medical Oncology, University of Texas Health Science Center at San Antonio (UTHSCSA)
- Nathan Harper
- Division of Infectious Diseases, University of Texas Health Science Center at San Antonio (UTHSCSA)
- Chris E. Shannon
- Division of Diabetes, Department of Medicine, University of Texas Health Science Center at San Antonio (UTHSCSA)
- Marcel Fourcaudot
- Division of Diabetes, Department of Medicine, University of Texas Health Science Center at San Antonio (UTHSCSA)
- Zhi Li
- Department of Cellular Systems and Anatomy, University of Texas Health Science Center at San Antonio (UTHSCSA)
- Balakuntalam S. Kasinath
- Division of Nephrology, Department of Medicine, University of Texas Health Science Center at San Antonio (UTHSCSA)
- Stephen Harrison
- Radcliffe Department of Medicine, University of Oxford
- Sunil Ahuja
- Division of Infectious Diseases, University of Texas Health Science Center at San Antonio (UTHSCSA)
- Robert L. Reddick
- Department of Pathology, UTHSCSA, 7703 Floyd Curl Drive
- Lily Q. Dong
- Department of Cellular Systems and Anatomy, University of Texas Health Science Center at San Antonio (UTHSCSA)
- Muhammad Abdul-Ghani
- Division of Diabetes, Department of Medicine, University of Texas Health Science Center at San Antonio (UTHSCSA)
- Luke Norton
- Division of Diabetes, Department of Medicine, University of Texas Health Science Center at San Antonio (UTHSCSA)
- Ricardo C. T. Aguiar
- Division of Hematology and Medical Oncology, University of Texas Health Science Center at San Antonio (UTHSCSA)
- Patricia L. M. Dahia
- Division of Hematology and Medical Oncology, University of Texas Health Science Center at San Antonio (UTHSCSA)
- DOI
- https://doi.org/10.1038/s41467-019-12661-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
TMEM127 is a tumor suppressor protein, loss of which predisposes to catecholamine-secreting tumors. Here the authors show that TMEM127 expression is modulated by nutritional status and that it has a role in regulating organismal insulin sensitivity.
