Structure and mechanism of the RNA dependent RNase Cas13a from Rhodobacter capsulatus

Leonhard M. Kick; Marie-Kristin von Wrisberg; Leander S. Runtsch; Sabine Schneider

doi:10.1038/s42003-022-03025-4

Communications Biology (Jan 2022)

Structure and mechanism of the RNA dependent RNase Cas13a from Rhodobacter capsulatus

Leonhard M. Kick,
Marie-Kristin von Wrisberg,
Leander S. Runtsch,
Sabine Schneider

Affiliations

Leonhard M. Kick: Ludwig-Maximilians University, Department of Chemistry, Institute for Chemical Epigenetics
Marie-Kristin von Wrisberg: Ludwig-Maximilians University, Department of Chemistry, Institute for Chemical Epigenetics
Leander S. Runtsch: Ludwig-Maximilians University, Department of Chemistry, Institute for Chemical Epigenetics
Sabine Schneider: Ludwig-Maximilians University, Department of Chemistry, Institute for Chemical Epigenetics

DOI: https://doi.org/10.1038/s42003-022-03025-4
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 9

Abstract

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The structure of the Cas13a RNase from the purple bacterium R. capsulatus in complex with its crRNA is reported here. The study reveals that the enzyme combines shape and sequence-specific readout to recognize its crRNA.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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