CEREBRAL CIRCULATION AND COGNITIVE STATUS OF CORONARY HEART DISEASE PATIENTS AFTER BYPASS SURGERY

Abstract

Aim. To assess the condition of cerebral blood flow and cognitive functions in coronary heart disease (CHD) patients underwent on-pump coronary bypass surgery and to evaluate the influence of citicoline on the condition of higher cerebral functions during early and delayed follow-up after the surgery.Material and methods. At the Federal Center of Cardiovascular Surgery (Krasnoyarsk city), 66 patients investigated, with CHD. Patients were selected to two groups. In the main group (n=36) as a cerebral protector citicoline was used intravenously pre-operation, dosage 1000 mg on 200 mL 0,9% saline, and then 7 days after operation with further intake 900 mg daily for 2 months. Comparison group (n=30) did not undergo cerebroprotection in perioperational period.Results. By the 12th month after surgery, the parameters of cognition returned to baseline. In the controls, cognitive function returned to baseline only by the test “visual verbal memory” (direct reproduction).Conclusion. Neuroprotection by citicoline can be regarded as a method for improvement of cognitive functioning after such harming influences as on-pump surgery, and therefore to reach higher everyday functioning abilities after coronary bypass.

Keywords

• ишемическая болезнь сердца
• когнитивные нарушения
• послеоперационная когнитивная дисфункция
• коронарное шунтирование
• транскраниальная доплерография
• нейропротектиная терапия