Briarenols Q–T: Briaranes from A Cultured Octocoral <i>Briareum stechei</i> (Kükenthal, 1908)
Yi-Lin Zhang,
Chih-Chao Chiang,
Yi-Ting Lee,
Zhi-Hong Wen,
Yang-Chang Wu,
Yu-Jen Wu,
Tsong-Long Hwang,
Tung-Ying Wu,
Chia-Yuan Chang,
Ping-Jyun Sung
Affiliations
Yi-Lin Zhang
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944401, Taiwan
Chih-Chao Chiang
Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan
Yi-Ting Lee
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan
Zhi-Hong Wen
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan
Yang-Chang Wu
Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404333, Taiwan
Yu-Jen Wu
Department of Nursing, Meiho University, Pingtung 912009, Taiwan
Tsong-Long Hwang
Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan
Tung-Ying Wu
Department of Biological Science & Technology, Meiho University, Pingtung 912009, Taiwan
Chia-Yuan Chang
Department of Neurosurgery, Antai Medical Care Corporation Antai Tian-Sheng Memorial Hospital, Pingtung 928004, Taiwan
Ping-Jyun Sung
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944401, Taiwan
Our continuous chemical study of a cultured octocoral Briareum stechei led to the isolation of four new briarane diterpenoids, briarenols Q–T (1–4). The structures of new metabolites 1–4 were established by spectroscopic methods, and compounds 3 and 4 were found to inhibit the generation of inducible nitric oxide synthase (iNOS) from RAW 264.7 stimulated by lipopolysaccharides (LPS).
