Cortex-wide neural interfacing via transparent polymer skulls

Leila Ghanbari; Russell E. Carter; Mathew L. Rynes; Judith Dominguez; Gang Chen; Anant Naik; Jia Hu; Md Abdul Kader Sagar; Lenora Haltom; Nahom Mossazghi; Madelyn M. Gray; Sarah L. West; Kevin W. Eliceiri; Timothy J. Ebner; Suhasa B. Kodandaramaiah

doi:10.1038/s41467-019-09488-0

Nature Communications (Apr 2019)

Cortex-wide neural interfacing via transparent polymer skulls

Leila Ghanbari,
Russell E. Carter,
Mathew L. Rynes,
Judith Dominguez,
Gang Chen,
Anant Naik,
Jia Hu,
Md Abdul Kader Sagar,
Lenora Haltom,
Nahom Mossazghi,
Madelyn M. Gray,
Sarah L. West,
Kevin W. Eliceiri,
Timothy J. Ebner,
Suhasa B. Kodandaramaiah

Affiliations

Leila Ghanbari: Department of Mechanical Engineering, University of Minnesota
Russell E. Carter: Department of Neuroscience, University of Minnesota
Mathew L. Rynes: Department of Biomedical Engineering, University of Minnesota
Judith Dominguez: Department of Mechanical Engineering, University of Minnesota
Gang Chen: Department of Neuroscience, University of Minnesota
Anant Naik: Department of Biomedical Engineering, University of Minnesota
Jia Hu: Department of Biomedical Engineering, University of Minnesota
Md Abdul Kader Sagar: Department of Biomedical Engineering, University of Wisconsin
Lenora Haltom: Department of Mechanical Engineering, University of Minnesota
Nahom Mossazghi: Department of Neuroscience, University of Minnesota
Madelyn M. Gray: Department of Neuroscience, University of Minnesota
Sarah L. West: Department of Neuroscience, University of Minnesota
Kevin W. Eliceiri: Department of Biomedical Engineering, University of Wisconsin
Timothy J. Ebner: Department of Neuroscience, University of Minnesota
Suhasa B. Kodandaramaiah: Department of Mechanical Engineering, University of Minnesota

DOI: https://doi.org/10.1038/s41467-019-09488-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

Read online

Imaging the mouse brain using glass cranial windows has limitations in terms of flexibility and long-term imaging. Here the authors engineer transparent polymer skulls that can fit various skull morphologies and can be implanted for over 300 days, enabling simultaneous high resolution brain imaging and electrophysiology across large cortical areas.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal