MTA2 triggered R-loop trans-regulates BDH1-mediated β-hydroxybutyrylation and potentiates propagation of hepatocellular carcinoma stem cells

• Heng Zhang,
• Zhi Chang,
• Lu-ning Qin,
• Bin Liang,
• Jing-xia Han,
• Kai-liang Qiao,
• Cheng Yang,
• Yan-rong Liu,
• Hong-gang Zhou,
• Tao Sun

Affiliations

Heng Zhang

State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University

Zhi Chang

State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University

Lu-ning Qin

State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University

Bin Liang

Tianjin Key Laboratory of Early Druggability Evaluation of Innovative Drugs and Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine

Jing-xia Han

Tianjin Key Laboratory of Early Druggability Evaluation of Innovative Drugs and Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine

Kai-liang Qiao

State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University

Cheng Yang

State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University

Yan-rong Liu

Tianjin Key Laboratory of Early Druggability Evaluation of Innovative Drugs and Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine

Hong-gang Zhou

State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University

Tao Sun

State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University