Uncommon finding in a pulmonary graft versus host disease: A first report of Tsukamurella pneumonia in a pulmonary graft-versus-host disease
F.R. Bertuccio,
N. Baio,
V. Chino,
S. Montini,
P. Putignano,
L. Pisanu,
M. Siciliano,
J. Bagnarino,
V. Monzillo,
D. Barbarini,
V. Conio,
A. Cascina,
G. Stella,
A.G. Corsico
Affiliations
F.R. Bertuccio
Cardiothoracic and Vascular Department, Unit of Respiratory Disease, IRCCS Policlinico San Matteo, 27100 Pavia, Italy; Department of Internal Medicine and Pharmacology, University of Pavia, Pavia 27100, Italy; Correspondence to: Viale Camillo Golgi 19, 27100 Pavia, Italy.
N. Baio
Cardiothoracic and Vascular Department, Unit of Respiratory Disease, IRCCS Policlinico San Matteo, 27100 Pavia, Italy; Department of Internal Medicine and Pharmacology, University of Pavia, Pavia 27100, Italy
V. Chino
Ospedale Pederzoli, 37019 Peschiera del Garda, Verona, Italy
S. Montini
Cardiothoracic and Vascular Department, Unit of Respiratory Disease, IRCCS Policlinico San Matteo, 27100 Pavia, Italy; Department of Internal Medicine and Pharmacology, University of Pavia, Pavia 27100, Italy
P. Putignano
Cardiothoracic and Vascular Department, Unit of Respiratory Disease, IRCCS Policlinico San Matteo, 27100 Pavia, Italy; Department of Internal Medicine and Pharmacology, University of Pavia, Pavia 27100, Italy
L. Pisanu
Cardiothoracic and Vascular Department, Unit of Respiratory Disease, IRCCS Policlinico San Matteo, 27100 Pavia, Italy; Department of Internal Medicine and Pharmacology, University of Pavia, Pavia 27100, Italy
M. Siciliano
Department of Internal Medicine and Pharmacology, University of Pavia, Pavia 27100, Italy; Microbiology and Virology Unit IRCCS, 27100 Pavia, Italy
J. Bagnarino
Department of Internal Medicine and Pharmacology, University of Pavia, Pavia 27100, Italy; Microbiology and Virology Unit IRCCS, 27100 Pavia, Italy
V. Monzillo
Department of Internal Medicine and Pharmacology, University of Pavia, Pavia 27100, Italy; Microbiology and Virology Unit IRCCS, 27100 Pavia, Italy
D. Barbarini
Department of Internal Medicine and Pharmacology, University of Pavia, Pavia 27100, Italy; Microbiology and Virology Unit IRCCS, 27100 Pavia, Italy
V. Conio
Cardiothoracic and Vascular Department, Unit of Respiratory Disease, IRCCS Policlinico San Matteo, 27100 Pavia, Italy; Department of Internal Medicine and Pharmacology, University of Pavia, Pavia 27100, Italy
A. Cascina
Cardiothoracic and Vascular Department, Unit of Respiratory Disease, IRCCS Policlinico San Matteo, 27100 Pavia, Italy; Department of Internal Medicine and Pharmacology, University of Pavia, Pavia 27100, Italy
G. Stella
Cardiothoracic and Vascular Department, Unit of Respiratory Disease, IRCCS Policlinico San Matteo, 27100 Pavia, Italy; Department of Internal Medicine and Pharmacology, University of Pavia, Pavia 27100, Italy
A.G. Corsico
Cardiothoracic and Vascular Department, Unit of Respiratory Disease, IRCCS Policlinico San Matteo, 27100 Pavia, Italy; Department of Internal Medicine and Pharmacology, University of Pavia, Pavia 27100, Italy
A 64-year-old woman presented to Our Department with 2 weeks history of fever and cough. Through a series of radiological and invasive diagnostic studies we finally reach an unexpected diagnosis of Tsukamurella pneumonia; Diagnosing an ILD is a dynamic process, and that is the reason why complex cases discussed in a multidisciplinary team may need to be reconsidered in light of evolution of the disease and the results of the performed exams with a flexible approach. Tsukamurella spp. is an obligate aerobic, Gram-positive, weakly acid-fast, non-motile bacillus that belongs to the order Actinomycetales. Pneumonia caused by Tsukamurella is exceedingly rare, and only few cases are reported in the literature. Our aim is to evidence the paramount importance of Multidisciplinary team discussion in deciding the most appropriate diagnostic is of and therapeutical strategy.
