Molecules
(Aug 2022)
Synthesis of Functionalized Azepines via Cu(I)-Catalyzed Tandem Amination/Cyclization Reaction of Fluorinated Allenynes
Anna N. Philippova,
Daria V. Vorobyeva,
Pavel S. Gribanov,
Ivan A. Godovikov,
Sergey N. Osipov
Affiliations
Anna N. Philippova
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilova str., Moscow 119991, Russia
Daria V. Vorobyeva
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilova str., Moscow 119991, Russia
Pavel S. Gribanov
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilova str., Moscow 119991, Russia
Ivan A. Godovikov
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilova str., Moscow 119991, Russia
Sergey N. Osipov
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilova str., Moscow 119991, Russia
DOI
https://doi.org/10.3390/molecules27165195
Journal volume & issue
Vol. 27,
no. 16
Abstract
Read online
An efficient method for the selective preparation of trifluoromethyl-substituted azepin-2-carboxylates and their phosphorous analogues has been developed via Cu(I)-catalyzed tandem amination/cyclization reaction of functionalized allenynes with primary and secondary amines.
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