The CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation

Shixuan Wang; Aimin Liu; Guangyu Wu; Han-Fei Ding; Shuang Huang; Stanley Nahman; Zheng Dong

doi:10.1038/s41467-018-03628-8

Nature Communications (Mar 2018)

The CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation

Shixuan Wang,
Aimin Liu,
Guangyu Wu,
Han-Fei Ding,
Shuang Huang,
Stanley Nahman,
Zheng Dong

Affiliations

Shixuan Wang: Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood VA Medical Center
Aimin Liu: Department of Biology, Eberly College of Sciences, Huck Institute of the Life Sciences, The Pennsylvania State University
Guangyu Wu: Department of Pharmacology and Toxicology, Medical College of Georgia at Augusta University
Han-Fei Ding: Cancer Center and Department of Pathology, Medical College of Georgia at Augusta University
Shuang Huang: Department of Anatomy and Cell Biology, University of Florida College of Medicine
Stanley Nahman: Department of Medicine, Medical College of Georgia at Augusta University
Zheng Dong: Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood VA Medical Center

DOI: https://doi.org/10.1038/s41467-018-03628-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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Intu is a planar cell polarity protein known to regulate ciliogenesis during embryonic development. Here, Wang et al. identify a role for Intu in adult kidneys, where they find it promotes degradation of STAT1 and thus prevents cilia loss and cell death upon ischemia-reperfusion injury.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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